Lab Publications
Find Pidot Lab publications on PubMed
2024
Muhi S, Buultjens AH, Porter JL, Marshall JL, Doerflinger M, Pidot SJ, O'Brien DP, Johnson PDR, Lavender CJ, Globan M, McCarthy J, Osowicki J, Stinear TP. Mycobacterium ulcerans challenge strain selection for a Buruli ulcer controlled human infection model. PLoS Negl Trop Dis. 2024 May 3;18(5):e0011979. doi: 10.1371/journal.pntd.0011979
Richter I, Hasan M, Kramer JW, Wein P, Krabbe J, Woitas KP, Stinear TP, Pidot SJ, Kloss F, Hertweck C, Lackner G. Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction. ISME J. 2024 May 1:wrae074. doi: 10.1093/ismejo/wrae074.
Little RF, Trottmann F, Hashizume H, Preissler M, Unger S, Sawa R, Kries H, Pidot S, Igarashi M, Hertweck C. Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds. ACS Chem Biol. 2024 Mar 15;19(3):660-668. doi: 10.1021/acschembio.3c00648
Kaur A, Pickles IB, Sharma M, Madeido Soler N, Scott NE, Pidot SJ, Goddard-Borger ED, Davies GJ, Williams SJ. Widespread Family of NAD+-Dependent Sulfoquinovosidases at the Gateway to Sulfoquinovose Catabolism. J Am Chem Soc. 2023 Dec 27;145(51):28216-28223. doi: 10.1021/jacs.3c11126.
2023
Richter I, Uzum Z, Wein P, Molloy EM, Moebius N, Stinear TP, Pidot SJ, Hertweck C. Transcription activator-like effectors from endosymbiotic bacteria control the reproduction of their fungal host. mBio. 2023 Nov 16:e0182423. doi: 10.1128/mbio.01824-23.
Sharkey LKR, Guerillot R, Walsh CJ, Turner AM, Lee JYH, Neville SL, Klatt S, Baines SL, Pidot SJ, Rossello FJ, Seemann T, McWilliam HEG, Cho E, Carter GP, Howden BP, McDevitt CA, Hachani A, Stinear TP, Monk IR. The two-component system WalKR provides an essential link between cell wall homeostasis and DNA replication in Staphylococcus aureus. mBio. 2023 Oct 16:e0226223. doi: 10.1128/mbio.02262-23.
Ehinger FJ, Niehs SP, Dose B, Dell M, Krabbe J, Pidot SJ, Stinear TP, Scherlach K, Ross C, Lackner G, Hertweck C. Analysis of Rhizonin Biosynthesis Reveals Origin of Pharmacophoric Furylalanine Moieties in Diverse Cyclopeptides. Angew Chem Int Ed. 2023 Oct 16;62(42):e202308540. doi: 10.1002/anie.202308540.
Doering T, Tandon K, Topa SH, Pidot SJ, Blackall LL, van Oppen MJH. Genomic exploration of coral-associated bacteria: identifying probiotic candidates to increase coral bleaching resilience in Galaxea fascicularis. Microbiome. 2023 Aug 19;11(1):185. doi: 10.1186/s40168-023-01622-x.
Herisse M, Ishida K, Staiger-Creed J, Judd L, Williams SJ, Howden BP, Stinear TP, Dahse HM, Voigt K, Hertweck C, Pidot SJ.
Discovery and Biosynthesis of the Cytotoxic Polyene Terpenomycin in Human Pathogenic Nocardia. ACS Chem Biol. 2023 Aug 18;18(8):1872-1879. doi: 10.1021/acschembio.3c00311.
Muhi S, Osowicki J, O'Brien D, Johnson PDR, Pidot S, Doerflinger M, Marshall JL, Pellegrini M, McCarthy J, Stinear TP. A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain. PLoS Negl Trop Dis. 2023 Jun 29;17(6):e0011394. doi: 10.1371/journal.pntd.0011394.
Awori RM, Waturu CN, Pidot SJ, Amugune NO, Bode HB. Draft genomes, phylogenomic reconstruction and comparative genome analysis of three Xenorhabdus strains isolated from soil-dwelling nematodes in Kenya. Access Microbiol. 2023 May 22;5(5):acmi000531.v4. doi: 10.1099/acmi.0.000531.v4.
Hachani A, Giulieri SG, Guérillot R, Walsh CJ, Herisse M, Soe YM, Baines SL, Thomas DR, Cheung SD, Hayes AS, Cho E, Newton HJ, Pidot S, Massey RC, Howden BP, Stinear TP. A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence. Elife. 2023 Jun 8;12:e84778. doi: 10.7554/eLife.84778.
Kaur A, Scott NE, Herisse M, Goddard-Borger ED, Pidot S, Williams SJ. Identification of levoglucosan degradation pathways in bacteria and sequence similarity network analysis. Arch Microbiol 2023 Mar 31;205(4):155. doi: 10.1007/s00203-023-03506-y.
2022
Niehs SP, Scherlach K, Dose B, Uzum Z, Stinear TP, Pidot SJ, Hertweck C. A highly conserved gene locus in endofungal bacteria codes for the biosynthesis of symbiosis-specific cyclopeptides. PNAS Nexus, 2022,1(4), pgac152, doi: 10.1093/pnasnexus/pgac152
Shi YM, Hirschmann M, Shi YN, Ahmed S, Abebew D, Tobias NJ, Grün P, Crames JJ, Pöschel L, Kuttenlochner W, Richter C, Herrmann J, Müller R, Thanwisai A, Pidot SJ, Stinear TP, Groll M, Kim Y, Bode HB. Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria. Nat Chem. 2022 Jun;14(6):701-712. doi: 10.1038/s41557-022-00923-2.
Herisse M, Pidot SJ. Mobilization of cryptic antibiotic biosynthesis loci from human-pathogenic Nocardia. Methods Enzymol. 2022;664:173-197. doi: 10.1016/bs.mie.2021.11.007.
Kaur A, van der Peet PL, Mui JW, Herisse M, Pidot S, Williams SJ. Genome sequences of Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway. Arch Microbiol. 2022 Feb 24;204(3):193. doi: 10.1007/s00203-022-02803-2.
2021
Chen R, Xue Y, Xu X, Yang H, Qiu T, Shui L, Wang X, Zhou G, Giersig M, Pidot S, Hutchison JA, Akinoglu EM. Lithography-free synthesis of periodic, vertically-aligned, multi-walled carbon nanotube arrays. Nanotechnology. 2021 Nov 18;33(6). doi: 10.1088/1361-6528/ac345a.
Büttner H, Niehs SP, Vandelannoote K, Cseresnyés Z, Dose B, Richter I, Gerst R, Figge MT, Stinear TP, Pidot SJ, Hertweck C. Bacterial endosymbionts protect beneficial soil fungus from nematode attack. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2110669118. doi: 10.1073/pnas.2110669118.
Mosquera KD, Martinez Villegas LE, Pidot SJ, Sharif C, Klimpel S, Stinear TP, Moreira LA, Tobias NJ, Lorenzo MG. Multi-Omic Analysis of Symbiotic Bacteria Associated With Aedes aegypti Breeding Sites. Front Microbiol. 2021 Aug 12;12:703711.
Vandelannoote K, Buultjens AH, Li L, Sharkey LK, Herisse M, Pidot SJ, Hoang T, Howden BP, Monk IR, Seemann T, Lee JYH, Stinear TP.Accessible Platform for High-Throughput COVID-19 Molecular Diagnostics and Genome Sequencing Using a Repurposed 3D Printer for RNA Extraction. ACS Biomater Sci Eng. 2021 Sep 13;7(9):4669-4676. doi: 10.1021/acsbiomaterials.1c00775.
Pidot SJ, Porter JL, Lister T, Stinear TP. In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera. PLoS Negl Trop Dis. 2021 Jul 26;15(7):e0009636. doi: 10.1371/journal.pntd.0009636.
2020
Neubacher N, Tobias NJ, Huber M, Cai X, Glatter T, Pidot SJ, Stinear TP, Lütticke AL, Papenfort K, Bode HB. Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nat Microbiol. 2020 Dec;5(12):1481-1489. doi: 10.1038/s41564-020-00797-5.
Kenshole E, Herisse M, Michael M, Pidot SJ. Natural product discovery through microbial genome mining. Curr Opin Chem Biol. 2020 Aug 24;60:47-54. doi: 10.1016/j.cbpa.2020.07.010.
Mangas KM, Tobias NJ, Marion E, Babonneau J, Marsollier L, Porter JL, Pidot SJ, Wong CY, Jackson DC, Chua BY, Stinear TP. High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice.
PeerJ. 2020 Aug 7;8:e9659. doi: 10.7717/peerj.9659.
Robinson SL, Terlouw BR, Smith MD, Pidot SJ, Stinear TP, Medema MH, Wackett LP. Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia. J Biol Chem. 2020 Aug 21:jbc.RA120.013528. doi: 10.1074/jbc.RA120.013528.
Lee JYH, Best N, McAuley J, Porter JL, Seemann T, Schultz MB, Sait M, Orlando N, Mercoulia K, Ballard SA, Druce J, Tran T, Catton MG, Pryor MJ, Cui HL, Luttick A, McDonald S, Greenhalgh A, Kwong JC, Sherry NL, Graham M, Hoang T, Herisse M, Pidot SJ, Williamson DA, Howden BP, Monk IR, Stinear TP. Validation of a single-step, single-tube reverse transcription loop-mediated isothermal amplification assay for rapid detection of SARS-CoV-2 RNA. J Med Microbiol. 2020 Aug 5. doi: 10.1099/jmm.0.001238.
Ishida K, Shabuer G, Schieferdecker S, Pidot SJ, Stinear TP, Knuepfer U, Cyrulies M, Hertweck C. Oak-Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins. Chemistry. 2020 Jun 29. doi: 10.1002/chem.202001939.
Niehs SP, Dose B, Richter S, Pidot SJ, Dahse HM, Stinear TP, Hertweck C. Mining Symbionts of a Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones. Angew Chem Int Ed Engl. 2020 May 11;59(20):7766-7771. doi: 10.1002/anie.201916007.
Lee BM, Harold LK, Almeida DV, Afriat-Jurnou L, Aung HL, Forde BM, Hards K, Pidot SJ, Ahmed FH, Mohamed AE, Taylor MC, West NP, Stinear TP, Greening C, Beatson SA, Nuermberger EL, Cook GM, Jackson CJ. Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathog. 2020 Feb 7;16(2):e1008287. doi: 10.1371/journal.ppat.1008287.
Mangas KM, Buultjens AH, Porter JL, Baines SL, Marion E, Marsollier L, Tobias NJ, Pidot SJ, Quinn KM, Price DJ, Kedzierska K, Zeng W, Jackson DC, Chua BY, Stinear TP. Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model. Infect Immun. 2020 Feb 20;88(3):e00753-19. doi: 10.1128/IAI.00753-19.
Bratovanov EV, Ishida K, Heinze B, Pidot SJ, Stinear TP, Hegemann JD, Marahiel MA, Hertweck C. Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria. ACS Chem Biol. 2020 May 15;15(5):1169-1176. doi: 10.1021/acschembio.9b00805.
Herisse M, Ishida K, Porter JL, Howden B, Hertweck C, Stinear TP, Pidot SJ. Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Nocardia Isolate. ACS Chem Biol. 2020 May 15;15(5):1161-1168. doi: 10.1021/acschembio.9b00763.
Pidot SJ, Rizzacasa MA. The Nargenicin Family of Oxa-Bridged Macrolide Antibiotics. Chemistry. 2020 Mar 2;26(13):2780-2792. doi: 10.1002/chem.201904053.
2019
Lee JYH, Carter GP, Pidot SJ, Guérillot R, Seemann T, Gonçalves da Silva A, Foster TJ, Howden BP, Stinear TP, Monk IR. Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification. mBio. 2019 Dec 17;10(6). pii: e02451-19. doi: 10.1128/mBio.02451-19.
Monk IR, Shaikh N, Begg SL, Gajdiss M, Sharkey LKR, Lee JYH, Pidot SJ, Seemann T, Kuiper M, Winnen B, Hvorup R, Collins BM, Bierbaum G, Udagedara SR, Morey JR, Pulyani N, Howden BP, Maher MJ, McDevitt CA, King GF, Stinear TP. Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nat Commun. 2019 Jul 11;10(1):3067.
Niehs SP, Dose B, Scherlach K, Pidot SJ, Stinear TP, Hertweck C. Genome mining reveals endopyrroles from a nonribosomal peptide assembly line triggered in fungal-bacterial symbiosis. ACS Chem Biol. 2019 Aug 16;14(8):1811-1818.
Hermenau R, Mehl JL, Ishida K, Dose B, Pidot SJ, Stinear TP, Hertweck C. Genomics-driven discovery of NO-donating diazeniumdiolate siderophores in diverse plant-associated bacteria. Angew Chem Int Ed Engl. 2019 Sep 9;58(37):13024-13029.
Schieferdecker S, Shabuer G, Letzel AC, Urbansky B, Ishida-Ito M, Ishida K, Cyrulies M, Dahse HM, Pidot S, Hertweck C. Biosynthesis of diverse antimicrobial and antiproliferative acyloins in anaerobic bacteria. ACS Chem Biol. 2019 Jul 19;14(7):1490-1497.
Gebel J, Gemein S, Kampf G, Pidot SJ, Buetti N, Exner M. Isopropanol at 60% and at 70% are effective against 'isopropanol-tolerant' Enterococcus faecium. J Hosp Infect. 2019 Sep;103(1):e88-e91.
Pidot SJ, Herisse M, Sharkey L, Atkin L, Porter JL, Seemann T, Howden BP, Rizzacasa MA, Stinear TP. Biosynthesis and ether-bridge formation in nargenicin macrolides. Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3996-4001.
2018 and earlier
Guérillot R, Li L, Baines S, Howden B, Schultz MB, Seemann T, Monk I, Pidot SJ, Gao W, Giulieri S, Gonçalves da Silva A, D'Agata A, Tomita T, Peleg AY, Stinear TP, Howden BP. Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq). Genome Med. 2018 Aug 31;10(1):63.
Loglo AD, Frimpong M, Sarpong Duah M, Sarfo F, Sarpong FN, Agbavor B, Boakye-Appiah JK, Abass KM, Dongyele M, Frempong M, Pidot S, Wansbrough-Jones M, Stinear TP, Roupie V, Huygen K, Phillips RO. IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection. PeerJ. 2018 Jul 31;6:e5294.
Pidot SJ*, Gao W*, Buultjens AH*, Monk IR, Guerillot R, Carter GP, Lee JYH, Lam MMC, Grayson ML, Ballard SA, Mahony AA, Grabsch EA, Kotsanas D, Korman TM, Coombs GW, Robinson JO, Gonçalves da Silva A, Seemann T, Howden BP, Johnson PDR, Stinear TP. Increasing tolerance of hospital Enterococcus faecium to handwash alcohols. Sci Transl Med. 2018 Aug 1;10(452). pii: eaar6115. *Joint lead authors
Herisse M, Porter JL, Guerillot R, Tomita T, Goncalves Da Silva A, Seemann T, Howden BP, Stinear TP*, Pidot SJ*. The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia. PeerJ. 2018 May 4;6:e4784. *Joint corresponding authors
Guérillot R, Gonçalves da Silva A, Monk I, Giulieri S, Tomita T, Alison E, Porter J, Pidot S, Gao W, Peleg AY, Seemann T, Stinear TP, Howden BP. Convergent evolution driven by rifampin exacerbates the global burden of drug-resistant Staphylococcus aureus. mSphere. 2018 Jan 24;3(1). pii: e00550-17.
Tobias NJ, Wolff H, Djahanschiri B, Grundmann F, Kronenwerth M, Shi YM, Simonyi S, Grün P, Shapiro-Ilan D, Pidot SJ, Stinear TP, Ebersberger I, Bode HB. Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nat Microbiol. 2017 Dec;2(12):1676-1685.
Buultjens AH, Chua KYL, Baines SL, Kwong J, Gao W, Cutcher Z, Adcock S, Ballard S, Schultz MB, Tomita T, Subasinghe N, Carter GP, Pidot SJ, Franklin L, Seemann T, Gonçalves Da Silva A, Howden BP, Stinear TP. A supervised statistical learning approach for accurate Legionella pneumophila source attribution during
outbreaks. Appl Environ Microbiol. 2017 Oct 17;83(21). pii: e01482-17.
Lee JYH, Monk IR, Pidot SJ, Singh S, Chua KYL, Seemann T, Stinear TP, Howden BP. Functional analysis of the first complete genome sequence of a multidrug resistant sequence type 2 Staphylococcus epidermidis. Microb Genom. 2016 Sep 20;2(9):e000077.
Bitto NJ, Chapman R, Pidot S, Costin A, Lo C, Choi J, D'Cruze T, Reynolds EC, Dashper SG, Turnbull L, Whitchurch CB, Stinear TP, Stacey KJ, Ferrero RL. Bacterial membrane vesicles transport their DNA cargo into host cells. Sci Rep. 2017 Aug 1;7(1):7072.
Wallace JR, Mangas KM, Porter JL, Marcsisin R, Pidot SJ, Howden B, Omansen TF, Zeng W, Axford JK, Johnson PDR, Stinear TP. Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer. PLoS Negl Trop Dis. 2017 Apr 14;11(4):e0005553.
Cai X, Shi YM, Pöhlmann N, Revermann O, Bahner I, Pidot SJ, Wesche F, Lackner H, Büchel C, Kaiser M, Richter C, Schwalbe H, Stinear TP, Zeeck A, Bode HB. Structure and biosynthesis of isatropolones, bioactive amine-scavenging fluorescent natural Products from Streptomyces Gö66. Angew Chem Int Ed Engl. 2017 Apr 24;56(18):4945-4949.
Mularski A, Wilksch J, Hanssen E, Li J, Tomita T, Pidot SJ, Stinear T, Separovic F, Strugnell D. A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule. Eur Biophys J. 2017 May;46(4):351-361.
Shabuer G*, Ishida K*, Pidot SJ*, Roth M, Dahse HM, Hertweck C. Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science. 2015 Nov 6;350(6261):670-4. *Joint lead authors
Letzel AC, Pidot SJ, Hertweck C. Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria. BMC Genomics. 2014 Nov 18;15:983.
Pidot S*, Ishida K*, Cyrulies M, Hertweck C. Discovery of clostrubin, an exceptional polyphenolic polyketide antibiotic from a strictly anaerobic bacterium. Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7856-9. *Joint lead authors
Roupie V, Pidot SJ, Einarsdottir T, Van Den Poel C, Jurion F, Stinear TP, Huygen K. Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice. PLoS Negl Trop Dis. 2014 Jan 2;8(1):e2604.
Scherlach K, Lackner G, Graupner K, Pidot S, Bretschneider T, Hertweck C. Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. Chembiochem. 2013 Dec 6;14(18):2439-43.
Pidot SJ*, Coyne S*, Kloss F, Hertweck C. Antibiotics from neglected bacterial sources. Int J Med Microbiol. 2014 Jan;304(1):14-22. *Joint lead authors
Kloss F, Pidot S, Goerls H, Friedrich T, Hertweck C. Formation of a dinuclear copper(I) complex from the Clostridium-derived antibiotic closthioamide. Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10745-8.
Porter JL, Tobias NJ, Pidot SJ, Falgner S, Tuck KL, Vettiger A, Hong H, Leadlay PF, Stinear TP. The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis. PLoS One. 2013 Jul
23;8(7):e70520.
Letzel AC*, Pidot SJ*, Hertweck C. A genomic approach to the cryptic secondary metabolome of the anaerobic world. Nat Prod Rep. 2013 Mar;30(3):392-428. *Joint lead authors
Pidot SJ, Porter JL, Tobias NJ, Anderson J, Catmull D, Seemann T, Kidd S, Davies JK, Reynolds E, Dashper S, Stinear TP. Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation. Mol Microbiol. 2010 Dec;78(5):1216-31.
Pidot SJ, Porter JL, Marsollier L, Chauty A, Migot-Nabias F, Badaut C, Bénard A, Ruf MT, Seemann T, Johnson PD, Davies JK, Jenkin GA, Pluschke G, Stinear TP. Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics. PLoS Negl Trop Dis. 2010 Nov 2;4(11):e872.
Fyfe JA, Lavender CJ, Handasyde KA, Legione AR, O'Brien CR, Stinear TP, Pidot SJ, Seemann T, Benbow ME, Wallace JR, McCowan C, Johnson PD. A major role for mammals in the ecology of Mycobacterium ulcerans. PLoS Negl Trop Dis. 2010 Aug 10;4(8):e791.
Pidot SJ, Asiedu K, Käser M, Fyfe JA, Stinear TP. Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species. PLoS Negl Trop Dis. 2010 Jul 27;4(7):e663.
Röltgen K, Qi W, Ruf MT, Mensah-Quainoo E, Pidot SJ, Seemann T, Stinear TP, Käser M, Yeboah-Manu D, Pluschke G. Single nucleotide polymorphism typing of Mycobacterium ulcerans reveals focal transmission of buruli ulcer in a highly endemic region of Ghana. PLoS Negl Trop Dis. 2010 Jul 20;4(7):e751.
Tobias NJ, Seemann T, Pidot SJ, Porter JL, Marsollier L, Marion E, Letournel F, Zakir T, Azuolas J, Wallace JR, Hong H, Davies JK, Howden BP, Johnson PD, Jenkin GA, Stinear TP. Mycolactone gene expression is controlled by strong
SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer. PLoS Negl Trop Dis. 2009 Nov 24;3(11):e553.
Chiarezza M, Lyras D, Pidot SJ, Flores-Díaz M, Awad MM, Kennedy CL, Cordner LM, Phumoonna T, Poon R, Hughes ML, Emmins JJ, Alape-Girón A, Rood JI. The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence. Infect Immun. 2009 Oct;77(10):4421-8.
Pidot SJ, Hong H, Seemann T, Porter JL, Yip MJ, Men A, Johnson M, Wilson P, Davies JK, Leadlay PF, Stinear TP. Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones. BMC Genomics. 2008 Oct 7;9:462. doi: 10.1186/1471-2164-9-462.
Hong H, Demangel C, Pidot SJ, Leadlay PF, Stinear T. Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep. 2008 Jun;25(3):447-54.
Stinear TP, Seemann T, Pidot S, Frigui W, Reysset G, Garnier T, Meurice G, Simon D, Bouchier C, Ma L, Tichit M, Porter JL, Ryan J, Johnson PD, Davies JK, Jenkin GA, Small PL, Jones LM, Tekaia F, Laval F, Daffé M, Parkhill J, Cole ST. Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res. 2007
Feb;17(2):192-200.
Bannam TL, Johanesen PA, Salvado CL, Pidot SJ, Farrow KA, Rood JI. The Clostridium perfringens TetA(P) efflux protein contains a functional variant of the Motif A region found in major facilitator superfamily transport proteins.
Microbiology. 2004 Jan;150(Pt 1):127-34.
Find Pidot Lab publications on PubMed
2024
Muhi S, Buultjens AH, Porter JL, Marshall JL, Doerflinger M, Pidot SJ, O'Brien DP, Johnson PDR, Lavender CJ, Globan M, McCarthy J, Osowicki J, Stinear TP. Mycobacterium ulcerans challenge strain selection for a Buruli ulcer controlled human infection model. PLoS Negl Trop Dis. 2024 May 3;18(5):e0011979. doi: 10.1371/journal.pntd.0011979
Richter I, Hasan M, Kramer JW, Wein P, Krabbe J, Woitas KP, Stinear TP, Pidot SJ, Kloss F, Hertweck C, Lackner G. Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction. ISME J. 2024 May 1:wrae074. doi: 10.1093/ismejo/wrae074.
Little RF, Trottmann F, Hashizume H, Preissler M, Unger S, Sawa R, Kries H, Pidot S, Igarashi M, Hertweck C. Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds. ACS Chem Biol. 2024 Mar 15;19(3):660-668. doi: 10.1021/acschembio.3c00648
Kaur A, Pickles IB, Sharma M, Madeido Soler N, Scott NE, Pidot SJ, Goddard-Borger ED, Davies GJ, Williams SJ. Widespread Family of NAD+-Dependent Sulfoquinovosidases at the Gateway to Sulfoquinovose Catabolism. J Am Chem Soc. 2023 Dec 27;145(51):28216-28223. doi: 10.1021/jacs.3c11126.
2023
Richter I, Uzum Z, Wein P, Molloy EM, Moebius N, Stinear TP, Pidot SJ, Hertweck C. Transcription activator-like effectors from endosymbiotic bacteria control the reproduction of their fungal host. mBio. 2023 Nov 16:e0182423. doi: 10.1128/mbio.01824-23.
Sharkey LKR, Guerillot R, Walsh CJ, Turner AM, Lee JYH, Neville SL, Klatt S, Baines SL, Pidot SJ, Rossello FJ, Seemann T, McWilliam HEG, Cho E, Carter GP, Howden BP, McDevitt CA, Hachani A, Stinear TP, Monk IR. The two-component system WalKR provides an essential link between cell wall homeostasis and DNA replication in Staphylococcus aureus. mBio. 2023 Oct 16:e0226223. doi: 10.1128/mbio.02262-23.
Ehinger FJ, Niehs SP, Dose B, Dell M, Krabbe J, Pidot SJ, Stinear TP, Scherlach K, Ross C, Lackner G, Hertweck C. Analysis of Rhizonin Biosynthesis Reveals Origin of Pharmacophoric Furylalanine Moieties in Diverse Cyclopeptides. Angew Chem Int Ed. 2023 Oct 16;62(42):e202308540. doi: 10.1002/anie.202308540.
Doering T, Tandon K, Topa SH, Pidot SJ, Blackall LL, van Oppen MJH. Genomic exploration of coral-associated bacteria: identifying probiotic candidates to increase coral bleaching resilience in Galaxea fascicularis. Microbiome. 2023 Aug 19;11(1):185. doi: 10.1186/s40168-023-01622-x.
Herisse M, Ishida K, Staiger-Creed J, Judd L, Williams SJ, Howden BP, Stinear TP, Dahse HM, Voigt K, Hertweck C, Pidot SJ.
Discovery and Biosynthesis of the Cytotoxic Polyene Terpenomycin in Human Pathogenic Nocardia. ACS Chem Biol. 2023 Aug 18;18(8):1872-1879. doi: 10.1021/acschembio.3c00311.
Muhi S, Osowicki J, O'Brien D, Johnson PDR, Pidot S, Doerflinger M, Marshall JL, Pellegrini M, McCarthy J, Stinear TP. A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain. PLoS Negl Trop Dis. 2023 Jun 29;17(6):e0011394. doi: 10.1371/journal.pntd.0011394.
Awori RM, Waturu CN, Pidot SJ, Amugune NO, Bode HB. Draft genomes, phylogenomic reconstruction and comparative genome analysis of three Xenorhabdus strains isolated from soil-dwelling nematodes in Kenya. Access Microbiol. 2023 May 22;5(5):acmi000531.v4. doi: 10.1099/acmi.0.000531.v4.
Hachani A, Giulieri SG, Guérillot R, Walsh CJ, Herisse M, Soe YM, Baines SL, Thomas DR, Cheung SD, Hayes AS, Cho E, Newton HJ, Pidot S, Massey RC, Howden BP, Stinear TP. A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence. Elife. 2023 Jun 8;12:e84778. doi: 10.7554/eLife.84778.
Kaur A, Scott NE, Herisse M, Goddard-Borger ED, Pidot S, Williams SJ. Identification of levoglucosan degradation pathways in bacteria and sequence similarity network analysis. Arch Microbiol 2023 Mar 31;205(4):155. doi: 10.1007/s00203-023-03506-y.
2022
Niehs SP, Scherlach K, Dose B, Uzum Z, Stinear TP, Pidot SJ, Hertweck C. A highly conserved gene locus in endofungal bacteria codes for the biosynthesis of symbiosis-specific cyclopeptides. PNAS Nexus, 2022,1(4), pgac152, doi: 10.1093/pnasnexus/pgac152
Shi YM, Hirschmann M, Shi YN, Ahmed S, Abebew D, Tobias NJ, Grün P, Crames JJ, Pöschel L, Kuttenlochner W, Richter C, Herrmann J, Müller R, Thanwisai A, Pidot SJ, Stinear TP, Groll M, Kim Y, Bode HB. Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria. Nat Chem. 2022 Jun;14(6):701-712. doi: 10.1038/s41557-022-00923-2.
Herisse M, Pidot SJ. Mobilization of cryptic antibiotic biosynthesis loci from human-pathogenic Nocardia. Methods Enzymol. 2022;664:173-197. doi: 10.1016/bs.mie.2021.11.007.
Kaur A, van der Peet PL, Mui JW, Herisse M, Pidot S, Williams SJ. Genome sequences of Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway. Arch Microbiol. 2022 Feb 24;204(3):193. doi: 10.1007/s00203-022-02803-2.
2021
Chen R, Xue Y, Xu X, Yang H, Qiu T, Shui L, Wang X, Zhou G, Giersig M, Pidot S, Hutchison JA, Akinoglu EM. Lithography-free synthesis of periodic, vertically-aligned, multi-walled carbon nanotube arrays. Nanotechnology. 2021 Nov 18;33(6). doi: 10.1088/1361-6528/ac345a.
Büttner H, Niehs SP, Vandelannoote K, Cseresnyés Z, Dose B, Richter I, Gerst R, Figge MT, Stinear TP, Pidot SJ, Hertweck C. Bacterial endosymbionts protect beneficial soil fungus from nematode attack. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2110669118. doi: 10.1073/pnas.2110669118.
Mosquera KD, Martinez Villegas LE, Pidot SJ, Sharif C, Klimpel S, Stinear TP, Moreira LA, Tobias NJ, Lorenzo MG. Multi-Omic Analysis of Symbiotic Bacteria Associated With Aedes aegypti Breeding Sites. Front Microbiol. 2021 Aug 12;12:703711.
Vandelannoote K, Buultjens AH, Li L, Sharkey LK, Herisse M, Pidot SJ, Hoang T, Howden BP, Monk IR, Seemann T, Lee JYH, Stinear TP.Accessible Platform for High-Throughput COVID-19 Molecular Diagnostics and Genome Sequencing Using a Repurposed 3D Printer for RNA Extraction. ACS Biomater Sci Eng. 2021 Sep 13;7(9):4669-4676. doi: 10.1021/acsbiomaterials.1c00775.
Pidot SJ, Porter JL, Lister T, Stinear TP. In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera. PLoS Negl Trop Dis. 2021 Jul 26;15(7):e0009636. doi: 10.1371/journal.pntd.0009636.
2020
Neubacher N, Tobias NJ, Huber M, Cai X, Glatter T, Pidot SJ, Stinear TP, Lütticke AL, Papenfort K, Bode HB. Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nat Microbiol. 2020 Dec;5(12):1481-1489. doi: 10.1038/s41564-020-00797-5.
Kenshole E, Herisse M, Michael M, Pidot SJ. Natural product discovery through microbial genome mining. Curr Opin Chem Biol. 2020 Aug 24;60:47-54. doi: 10.1016/j.cbpa.2020.07.010.
Mangas KM, Tobias NJ, Marion E, Babonneau J, Marsollier L, Porter JL, Pidot SJ, Wong CY, Jackson DC, Chua BY, Stinear TP. High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice.
PeerJ. 2020 Aug 7;8:e9659. doi: 10.7717/peerj.9659.
Robinson SL, Terlouw BR, Smith MD, Pidot SJ, Stinear TP, Medema MH, Wackett LP. Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia. J Biol Chem. 2020 Aug 21:jbc.RA120.013528. doi: 10.1074/jbc.RA120.013528.
Lee JYH, Best N, McAuley J, Porter JL, Seemann T, Schultz MB, Sait M, Orlando N, Mercoulia K, Ballard SA, Druce J, Tran T, Catton MG, Pryor MJ, Cui HL, Luttick A, McDonald S, Greenhalgh A, Kwong JC, Sherry NL, Graham M, Hoang T, Herisse M, Pidot SJ, Williamson DA, Howden BP, Monk IR, Stinear TP. Validation of a single-step, single-tube reverse transcription loop-mediated isothermal amplification assay for rapid detection of SARS-CoV-2 RNA. J Med Microbiol. 2020 Aug 5. doi: 10.1099/jmm.0.001238.
Ishida K, Shabuer G, Schieferdecker S, Pidot SJ, Stinear TP, Knuepfer U, Cyrulies M, Hertweck C. Oak-Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins. Chemistry. 2020 Jun 29. doi: 10.1002/chem.202001939.
Niehs SP, Dose B, Richter S, Pidot SJ, Dahse HM, Stinear TP, Hertweck C. Mining Symbionts of a Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones. Angew Chem Int Ed Engl. 2020 May 11;59(20):7766-7771. doi: 10.1002/anie.201916007.
Lee BM, Harold LK, Almeida DV, Afriat-Jurnou L, Aung HL, Forde BM, Hards K, Pidot SJ, Ahmed FH, Mohamed AE, Taylor MC, West NP, Stinear TP, Greening C, Beatson SA, Nuermberger EL, Cook GM, Jackson CJ. Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathog. 2020 Feb 7;16(2):e1008287. doi: 10.1371/journal.ppat.1008287.
Mangas KM, Buultjens AH, Porter JL, Baines SL, Marion E, Marsollier L, Tobias NJ, Pidot SJ, Quinn KM, Price DJ, Kedzierska K, Zeng W, Jackson DC, Chua BY, Stinear TP. Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model. Infect Immun. 2020 Feb 20;88(3):e00753-19. doi: 10.1128/IAI.00753-19.
Bratovanov EV, Ishida K, Heinze B, Pidot SJ, Stinear TP, Hegemann JD, Marahiel MA, Hertweck C. Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria. ACS Chem Biol. 2020 May 15;15(5):1169-1176. doi: 10.1021/acschembio.9b00805.
Herisse M, Ishida K, Porter JL, Howden B, Hertweck C, Stinear TP, Pidot SJ. Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Nocardia Isolate. ACS Chem Biol. 2020 May 15;15(5):1161-1168. doi: 10.1021/acschembio.9b00763.
Pidot SJ, Rizzacasa MA. The Nargenicin Family of Oxa-Bridged Macrolide Antibiotics. Chemistry. 2020 Mar 2;26(13):2780-2792. doi: 10.1002/chem.201904053.
2019
Lee JYH, Carter GP, Pidot SJ, Guérillot R, Seemann T, Gonçalves da Silva A, Foster TJ, Howden BP, Stinear TP, Monk IR. Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification. mBio. 2019 Dec 17;10(6). pii: e02451-19. doi: 10.1128/mBio.02451-19.
Monk IR, Shaikh N, Begg SL, Gajdiss M, Sharkey LKR, Lee JYH, Pidot SJ, Seemann T, Kuiper M, Winnen B, Hvorup R, Collins BM, Bierbaum G, Udagedara SR, Morey JR, Pulyani N, Howden BP, Maher MJ, McDevitt CA, King GF, Stinear TP. Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nat Commun. 2019 Jul 11;10(1):3067.
Niehs SP, Dose B, Scherlach K, Pidot SJ, Stinear TP, Hertweck C. Genome mining reveals endopyrroles from a nonribosomal peptide assembly line triggered in fungal-bacterial symbiosis. ACS Chem Biol. 2019 Aug 16;14(8):1811-1818.
Hermenau R, Mehl JL, Ishida K, Dose B, Pidot SJ, Stinear TP, Hertweck C. Genomics-driven discovery of NO-donating diazeniumdiolate siderophores in diverse plant-associated bacteria. Angew Chem Int Ed Engl. 2019 Sep 9;58(37):13024-13029.
Schieferdecker S, Shabuer G, Letzel AC, Urbansky B, Ishida-Ito M, Ishida K, Cyrulies M, Dahse HM, Pidot S, Hertweck C. Biosynthesis of diverse antimicrobial and antiproliferative acyloins in anaerobic bacteria. ACS Chem Biol. 2019 Jul 19;14(7):1490-1497.
Gebel J, Gemein S, Kampf G, Pidot SJ, Buetti N, Exner M. Isopropanol at 60% and at 70% are effective against 'isopropanol-tolerant' Enterococcus faecium. J Hosp Infect. 2019 Sep;103(1):e88-e91.
Pidot SJ, Herisse M, Sharkey L, Atkin L, Porter JL, Seemann T, Howden BP, Rizzacasa MA, Stinear TP. Biosynthesis and ether-bridge formation in nargenicin macrolides. Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3996-4001.
2018 and earlier
Guérillot R, Li L, Baines S, Howden B, Schultz MB, Seemann T, Monk I, Pidot SJ, Gao W, Giulieri S, Gonçalves da Silva A, D'Agata A, Tomita T, Peleg AY, Stinear TP, Howden BP. Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq). Genome Med. 2018 Aug 31;10(1):63.
Loglo AD, Frimpong M, Sarpong Duah M, Sarfo F, Sarpong FN, Agbavor B, Boakye-Appiah JK, Abass KM, Dongyele M, Frempong M, Pidot S, Wansbrough-Jones M, Stinear TP, Roupie V, Huygen K, Phillips RO. IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection. PeerJ. 2018 Jul 31;6:e5294.
Pidot SJ*, Gao W*, Buultjens AH*, Monk IR, Guerillot R, Carter GP, Lee JYH, Lam MMC, Grayson ML, Ballard SA, Mahony AA, Grabsch EA, Kotsanas D, Korman TM, Coombs GW, Robinson JO, Gonçalves da Silva A, Seemann T, Howden BP, Johnson PDR, Stinear TP. Increasing tolerance of hospital Enterococcus faecium to handwash alcohols. Sci Transl Med. 2018 Aug 1;10(452). pii: eaar6115. *Joint lead authors
Herisse M, Porter JL, Guerillot R, Tomita T, Goncalves Da Silva A, Seemann T, Howden BP, Stinear TP*, Pidot SJ*. The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia. PeerJ. 2018 May 4;6:e4784. *Joint corresponding authors
Guérillot R, Gonçalves da Silva A, Monk I, Giulieri S, Tomita T, Alison E, Porter J, Pidot S, Gao W, Peleg AY, Seemann T, Stinear TP, Howden BP. Convergent evolution driven by rifampin exacerbates the global burden of drug-resistant Staphylococcus aureus. mSphere. 2018 Jan 24;3(1). pii: e00550-17.
Tobias NJ, Wolff H, Djahanschiri B, Grundmann F, Kronenwerth M, Shi YM, Simonyi S, Grün P, Shapiro-Ilan D, Pidot SJ, Stinear TP, Ebersberger I, Bode HB. Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nat Microbiol. 2017 Dec;2(12):1676-1685.
Buultjens AH, Chua KYL, Baines SL, Kwong J, Gao W, Cutcher Z, Adcock S, Ballard S, Schultz MB, Tomita T, Subasinghe N, Carter GP, Pidot SJ, Franklin L, Seemann T, Gonçalves Da Silva A, Howden BP, Stinear TP. A supervised statistical learning approach for accurate Legionella pneumophila source attribution during
outbreaks. Appl Environ Microbiol. 2017 Oct 17;83(21). pii: e01482-17.
Lee JYH, Monk IR, Pidot SJ, Singh S, Chua KYL, Seemann T, Stinear TP, Howden BP. Functional analysis of the first complete genome sequence of a multidrug resistant sequence type 2 Staphylococcus epidermidis. Microb Genom. 2016 Sep 20;2(9):e000077.
Bitto NJ, Chapman R, Pidot S, Costin A, Lo C, Choi J, D'Cruze T, Reynolds EC, Dashper SG, Turnbull L, Whitchurch CB, Stinear TP, Stacey KJ, Ferrero RL. Bacterial membrane vesicles transport their DNA cargo into host cells. Sci Rep. 2017 Aug 1;7(1):7072.
Wallace JR, Mangas KM, Porter JL, Marcsisin R, Pidot SJ, Howden B, Omansen TF, Zeng W, Axford JK, Johnson PDR, Stinear TP. Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer. PLoS Negl Trop Dis. 2017 Apr 14;11(4):e0005553.
Cai X, Shi YM, Pöhlmann N, Revermann O, Bahner I, Pidot SJ, Wesche F, Lackner H, Büchel C, Kaiser M, Richter C, Schwalbe H, Stinear TP, Zeeck A, Bode HB. Structure and biosynthesis of isatropolones, bioactive amine-scavenging fluorescent natural Products from Streptomyces Gö66. Angew Chem Int Ed Engl. 2017 Apr 24;56(18):4945-4949.
Mularski A, Wilksch J, Hanssen E, Li J, Tomita T, Pidot SJ, Stinear T, Separovic F, Strugnell D. A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule. Eur Biophys J. 2017 May;46(4):351-361.
Shabuer G*, Ishida K*, Pidot SJ*, Roth M, Dahse HM, Hertweck C. Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science. 2015 Nov 6;350(6261):670-4. *Joint lead authors
Letzel AC, Pidot SJ, Hertweck C. Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria. BMC Genomics. 2014 Nov 18;15:983.
Pidot S*, Ishida K*, Cyrulies M, Hertweck C. Discovery of clostrubin, an exceptional polyphenolic polyketide antibiotic from a strictly anaerobic bacterium. Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7856-9. *Joint lead authors
Roupie V, Pidot SJ, Einarsdottir T, Van Den Poel C, Jurion F, Stinear TP, Huygen K. Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice. PLoS Negl Trop Dis. 2014 Jan 2;8(1):e2604.
Scherlach K, Lackner G, Graupner K, Pidot S, Bretschneider T, Hertweck C. Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. Chembiochem. 2013 Dec 6;14(18):2439-43.
Pidot SJ*, Coyne S*, Kloss F, Hertweck C. Antibiotics from neglected bacterial sources. Int J Med Microbiol. 2014 Jan;304(1):14-22. *Joint lead authors
Kloss F, Pidot S, Goerls H, Friedrich T, Hertweck C. Formation of a dinuclear copper(I) complex from the Clostridium-derived antibiotic closthioamide. Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10745-8.
Porter JL, Tobias NJ, Pidot SJ, Falgner S, Tuck KL, Vettiger A, Hong H, Leadlay PF, Stinear TP. The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis. PLoS One. 2013 Jul
23;8(7):e70520.
Letzel AC*, Pidot SJ*, Hertweck C. A genomic approach to the cryptic secondary metabolome of the anaerobic world. Nat Prod Rep. 2013 Mar;30(3):392-428. *Joint lead authors
Pidot SJ, Porter JL, Tobias NJ, Anderson J, Catmull D, Seemann T, Kidd S, Davies JK, Reynolds E, Dashper S, Stinear TP. Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation. Mol Microbiol. 2010 Dec;78(5):1216-31.
Pidot SJ, Porter JL, Marsollier L, Chauty A, Migot-Nabias F, Badaut C, Bénard A, Ruf MT, Seemann T, Johnson PD, Davies JK, Jenkin GA, Pluschke G, Stinear TP. Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics. PLoS Negl Trop Dis. 2010 Nov 2;4(11):e872.
Fyfe JA, Lavender CJ, Handasyde KA, Legione AR, O'Brien CR, Stinear TP, Pidot SJ, Seemann T, Benbow ME, Wallace JR, McCowan C, Johnson PD. A major role for mammals in the ecology of Mycobacterium ulcerans. PLoS Negl Trop Dis. 2010 Aug 10;4(8):e791.
Pidot SJ, Asiedu K, Käser M, Fyfe JA, Stinear TP. Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species. PLoS Negl Trop Dis. 2010 Jul 27;4(7):e663.
Röltgen K, Qi W, Ruf MT, Mensah-Quainoo E, Pidot SJ, Seemann T, Stinear TP, Käser M, Yeboah-Manu D, Pluschke G. Single nucleotide polymorphism typing of Mycobacterium ulcerans reveals focal transmission of buruli ulcer in a highly endemic region of Ghana. PLoS Negl Trop Dis. 2010 Jul 20;4(7):e751.
Tobias NJ, Seemann T, Pidot SJ, Porter JL, Marsollier L, Marion E, Letournel F, Zakir T, Azuolas J, Wallace JR, Hong H, Davies JK, Howden BP, Johnson PD, Jenkin GA, Stinear TP. Mycolactone gene expression is controlled by strong
SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer. PLoS Negl Trop Dis. 2009 Nov 24;3(11):e553.
Chiarezza M, Lyras D, Pidot SJ, Flores-Díaz M, Awad MM, Kennedy CL, Cordner LM, Phumoonna T, Poon R, Hughes ML, Emmins JJ, Alape-Girón A, Rood JI. The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence. Infect Immun. 2009 Oct;77(10):4421-8.
Pidot SJ, Hong H, Seemann T, Porter JL, Yip MJ, Men A, Johnson M, Wilson P, Davies JK, Leadlay PF, Stinear TP. Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones. BMC Genomics. 2008 Oct 7;9:462. doi: 10.1186/1471-2164-9-462.
Hong H, Demangel C, Pidot SJ, Leadlay PF, Stinear T. Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep. 2008 Jun;25(3):447-54.
Stinear TP, Seemann T, Pidot S, Frigui W, Reysset G, Garnier T, Meurice G, Simon D, Bouchier C, Ma L, Tichit M, Porter JL, Ryan J, Johnson PD, Davies JK, Jenkin GA, Small PL, Jones LM, Tekaia F, Laval F, Daffé M, Parkhill J, Cole ST. Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res. 2007
Feb;17(2):192-200.
Bannam TL, Johanesen PA, Salvado CL, Pidot SJ, Farrow KA, Rood JI. The Clostridium perfringens TetA(P) efflux protein contains a functional variant of the Motif A region found in major facilitator superfamily transport proteins.
Microbiology. 2004 Jan;150(Pt 1):127-34.